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TSMB General Books

Some Useful References for the Course

These are books you might find helpful, but they do not define the syllabus. The syllabus is what is presented in the Web Pages and links contained in them. Most of these books are for reference rather than purchase. Probably Biophysical Techniques by Iain Campbell (see below) comes closest to covering the course if you want to buy one book and is very recent, but there are sections in TSMB it does not include. Sheehan would be the second choice, but covers similar areas to Campbell and has similar gaps in coverage

Protein Structure -particularly if you have not done the Principles of Protein Structure Course

Introduction to Protein Structure, Branden, C. and Tooze, J. (1999) 2nd edition, Garland Publishing, New York.

Protein Structure and Function. Petsko, G and Ringe, D. (2003) New Science Press/Blackwell Publishing

Introduction to Protein Architecture: The Structural Biology of Proteins Lesk, A. (2000) Oxford University Press.

The Oxford Practical Approach Series

from OUP offers detailed books on the various techniques covered. These are usually not too mathematically complex and are a good guide as to what to do practically.

General and Biochemical

Protein Function: A practical Approach (1997) Tom Creighton ISBN 0-19-963615-X


Bioinformatics: Sequence, Structure and Databanks (2000) Ed by Des Higgins, and Willie Taylor

Protein Purification and Analysis

Protein Purification Techniques New Edition (2000) Edited by Simon Roe

Gel Electrophoresis of Proteins Edited by B. D. Hames 3rd Edition


Macrolmolecular Crystallography (2007) Ed Sanderson M. and Skelly A


Crystallization of Nucleic Acids and Proteins Ed Ducruix, A and Giegé, R. 2nd Edition


NMR of Macromolecules (1993) Edited by Gordon C. K. Roberts

Other Books

Molecular Biology

Molecular Cloning: A Laboratory Manual (Third Edition) By Joe Sambrook, and David Russell. Cold Spring Harbor Press ISBN 0-87969-577-3. This is the latest edition of what is usually known as 'Maniatis' who was the final author of the first two editions. It is the 'bible' of molecular biology but is very expensive


Biomolecular NMR Spectroscopy. Jeremy N. S. Evans (1995) OUP. This was an excellent textbook when it came out but some of it is starting to be dated.

Understanding NMR Spectroscopy James Keeler Wiley (2005) ISBN: 978-0-470-01787-6 This covers NMR theory more generally, but is regarded as one of the best explanations. Goes beyond the level of understanding of NMR tehory required for the course.

Protein NMR Spectroscopy, Second Edition: Principles and Practice (2006) by John Cavanagh , Wayne J. Fairbrother , Arthur G. Palmer III , Nicholas J. Skelton , Mark Rance ISBN 978-0121644918. Again much more detailed than required for the course.


Outline of Crystallography for Biologists David Blow (2002) OUP ISBN-10: 0198510519. David Blow was one of the pioneers of crystallography and this is a very well written book. Probably the best of these selections

Biomolecular Crystallography Bernhard Rupp (2009). Garland Science ISBN 978-0-8153-4081-2 Probably a bit detailed and expensive for this course but an excellent book.

Crystallography Made Crystal Clear Gale Rhodes (2006) 3rd Edition Academic Press ISBN 0-125870728

A very good guide made by a leading teacher of macromolecular structure.

Electron Microscopy of Proteins

Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State by Joachim Frank ISBN 978-0195182187

Biophysical Techniques

Biophysical Techniques Iain Campbell (2012) OUP ISBN-13: 978-0199642144,

Physical Biochemistry: Principles and Applications David Sheehan Second Edition (2009) Wiley ISBN 0-471-98663-1

C. Cantor and P.R. Schimmel 3 volumes (1980) WH Freeman. Still one of the best and most detailed texts for the underlying theory- clearly somewhat dated now.

Part I: The Conformation of Biological Macromolecules ISBN 0-7167-1188-5

Part II: Techniques for the Study of Biological Structure and Function ISBN 0-7167-1190-7

Part III: The Behavior of Biological Macromolecules ISBN 0-7167-1192-3